The difference may not be readily apparent, but it is important to acknowledge that using ethanol in an engine not specifically suited for it will result in a lower energy output per combustion cycle.
Typically, there will be a little decrease in miles per gallon and maybe a modest reduction in power. We are referring to a power range of 1 to 2 horsepower.
Regarding concerns about running, it will not result in any negative consequences. If my 1990s vehicles can operate well on e10 fuel, I am certain that you will likewise have no issues.
While it is true that ethanol may degrade rubbers that are not specifically formulated to withstand it, the very little amount of ethanol present in most situations is unlikely to cause any problems. In the near future, at the very least